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Sjoerdsma, Ann G.'s Starting with Serotonin: How a High-Rolling Father of Drug Discovery Repeatedly Beat the Odds 1st (first) edition by Sjoerdsma, Ann G. published by Improbable Books [Hardcover] (2008)

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Sjoerdsma, Ann G.'s Starting with Serotonin: How a High-Rolling Father of Drug Discovery Repeatedly Beat the Odds 1st (first) edition by Sjoerdsma, Ann G. published by Improbable Books [Hardcover] (2008)

4.85 58,586 ratings · 2,562 reviews
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Overview: When Albert Sjoerdsma, M.D., Ph.D., arrived at the National Institutes of Health in the early 1950s, hypertension still regularly debilitated and killed people. He resolved to change this. Sjoerdsma had read that, when given intravenously, serotonin dramatically elevated a person's blood pressure. Maybe, the young researcher reasoned, he could manipulate serotonin in the body, by blocking a key enzyme in its chemical "pathway," and bring blood pressure down. This was revolutionary thinking. Most drug discovery at the time was a matter of luck, not rational conception. And little was known about serotonin, a "garden-variety" neurotransmitter today, except that it played a role in blood clotting. For twenty years, Sjoerdsma explored wide-ranging, uncharted territory in his Experimental Therapeutics Branch of the National Heart Institute. Launched by his ground-breaking serotonin studies, he diagnosed and defined a cancer known as the carcinoid syndrome; established the mechanism of action of the first antidepressants, which originated in a major drug company's tuberculosis program; measured serotonin, dopamine, and other amines in bananas and other foods, discovered the antihypertensive, Aldomet, a former Top-10 drug; identified treatment for the skin scourge, scleroderma, and the unusual high-blood-pressure disorder, pheochromocytoma; probed the biochemical nature of rapid-eye movement sleep, and much, much more. Because of his inspired work at the NIH and the training he gave his young clinical associates--newly graduated physicians who later spread his research gospel to academia--the tough-talking and straight-shooting Sjoerdsma became known as the Father of Clinical Pharmacology. An advocate of designing drugs that work by inhibiting enzymes, Sjoerdsma went on to enjoy decades-long success as a worldwide leader in the pharmaceutical industry, eventually serving as president of the Merrell Dow Research Institute, headquartered in Cincinnati. With a talented cadre of scientists, the unpredictable innovator developed the first-ever rationally designed antiepileptic (Sabril), also used today to treat a devastating infantile spasm disorder, and the first-ever non-sedating antihistamine, Seldane, replaced in time by its metabolite, Allegra. His crowning glory was the first-ever 100-percent cure for deadly African sleeping sickness--a drug known simply as DFMO. Long before American eyes opened to Third World health tragedies, Sjoerdsma had a lab devoted to research on parasitic diseases, as well as more traditional cancer and heart disease programs. He also contributed to the early treatment of AIDS patients. Gifted at discovery, Al Sjoerdsma always practiced good science, "followed his nose," and optimized the experimental odds in his favor. The research that the Father of Clinical Pharmacology conducted--his brainstorming--still has relevance today in the era of gene-replacement therapy and "Big Pharma." "Starting with Serotonin" shows his prescription for scientific creative freedom and productivity in action--lead by lead by compelling lead.

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Published July 28, 2008
ISBN 132293584
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Ann Sjoerdsma
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Ann Sjoerdsma
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Ann Sjoerdsma is a writer and avid reader based in the Pacific Northwest. Before pursuing writing full-time, they spent over a decade working in education. When not working on their next book, Ann Sjoerdsma can usually be found hiking with their dog or trying out new coffee shops in their neighborhood.

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I was completely blown away. The author orchestrated a breathtaking finale. Truly a work of art. Worth every moment spent reading.
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I was completely blown away. The prose is exquisite. It’s accessible yet undeniably sophisticated. A true literary gem.
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A profoundly satisfying read. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. A true literary gem.
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Absolutely brilliant. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. An absolute must-read for connoisseurs of the genre.
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Exceeded all my expectations. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I am now a lifelong fan of this author.
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A decent, if standard, experience. Certain acts were fascinating, while others felt like a slight endeavor to complete. Perhaps more aligned with a different audience's tastes.
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Masterpiece from start to finish. The prose is exquisite. It’s accessible yet undeniably sophisticated. Worth every moment spent reading.
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I thoroughly enjoyed the elegance of it. A brilliant concept executed with flair. Just a few pacing choices I would change. A very distinguished novel.
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Cynthia Scott
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Took a moment to build, but the payoff was spectacular. The middle had a deliberate pace, but the climax was phenomenal. I would highly recommend this to discerning readers.
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Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. A true literary gem.
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I was completely blown away. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. I am now a lifelong fan of this author.
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I thoroughly enjoyed the elegance of it. The protagonist was compelling, though some subplots felt slightly overshadowed. Quite impressive overall.
Steven Allen
Steven Allen June 09, 2025
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I am now a lifelong fan of this author.
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I was completely blown away. The author orchestrated a breathtaking finale. Truly a work of art. I will undoubtedly revisit this masterpiece.
Barbara Martinez
Barbara Martinez September 14, 2025
I was completely blown away. The author orchestrated a breathtaking finale. Truly a work of art. An absolute must-read for connoisseurs of the genre.
Kimberly Smith
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Excellent, though slightly flawed. Beautiful writing, though I craved slightly more depth in the lore. Still, undeniably engaging. A very distinguished novel.
Eric Campbell
Eric Campbell October 17, 2024
Exceeded all my expectations. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
Stephanie King
Stephanie King December 01, 2025
Exceeded all my expectations. The author orchestrated a breathtaking finale. Truly a work of art. Worth every moment spent reading.
John Moore
John Moore January 19, 2024
I thoroughly enjoyed the elegance of it. Beautiful writing, though I craved slightly more depth in the lore. Still, undeniably engaging. A solid 4 stars from me.
Christopher Flores
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Masterpiece from start to finish. The prose is exquisite. It’s accessible yet undeniably sophisticated. A true literary gem.
Brian Nguyen
Brian Nguyen April 23, 2025
A profoundly satisfying read. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. A true literary gem.
Kenneth Smith
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It was adequate. Certain acts were fascinating, while others felt like a slight endeavor to complete. Perfectly average.
David Wilson
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It was adequate. Certain acts were fascinating, while others felt like a slight endeavor to complete. Unlikely to reread, but a reasonable expenditure of time.
Gary Nelson
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A profoundly satisfying read. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An effortless 5 stars.
Linda Reyes
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A very strong entry. It held my rapt attention, even when certain twists were telegraphed. A solid 4 stars from me.
Rebecca Garcia
Rebecca Garcia September 24, 2025
Excellent, though slightly flawed. It held my rapt attention, even when certain twists were telegraphed. A solid 4 stars from me.
Barbara Hernandez
Barbara Hernandez May 15, 2025
I find myself somewhat conflicted. It verged on repetitive in the second act. A more concise edit would have served it well. Perhaps more aligned with a different audience's tastes.
Elizabeth Collins
Elizabeth Collins May 12, 2024
I was completely blown away. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An effortless 5 stars.
Steven Edwards
Steven Edwards September 11, 2024
I find myself somewhat conflicted. Certain acts were fascinating, while others felt like a slight endeavor to complete. Suitable if your reading queue is empty.
Ashley Wright
Ashley Wright June 07, 2025
A profoundly satisfying read. The prose is exquisite. It’s accessible yet undeniably sophisticated. I am now a lifelong fan of this author.
Edward Hernandez
Edward Hernandez January 21, 2025
I was completely blown away. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. Worth every moment spent reading.
Brian Gomez
Brian Gomez August 20, 2024
A profoundly satisfying read. The prose is exquisite. It’s accessible yet undeniably sophisticated. A true literary gem.
George Ramirez
George Ramirez September 03, 2025
A highly sophisticated read. The protagonist was compelling, though some subplots felt slightly overshadowed. A solid 4 stars from me.
Lisa Perez
Lisa Perez July 10, 2024
Masterpiece from start to finish. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An absolute must-read for connoisseurs of the genre.
Margaret Jackson
Margaret Jackson March 01, 2025
I was completely blown away. I became deeply invested in the protagonist's journey. A masterclass in storytelling. Worth every moment spent reading.
Ashley Campbell
Ashley Campbell March 22, 2025
Not entirely to my refined tastes. The prose was competent, yet the characters lacked the depth I usually seek. Perhaps more aligned with a different audience's tastes.
Robert Scott
Robert Scott May 31, 2025
Exceeded all my expectations. I adored how the story unfolded. It kept me captivated without sacrificing elegance. I will undoubtedly revisit this masterpiece.
William Walker
William Walker May 21, 2025
Absolutely brilliant. I adored how the story unfolded. It kept me captivated without sacrificing elegance. I will undoubtedly revisit this masterpiece.
Kevin White
Kevin White September 05, 2025
I find myself somewhat conflicted. The tempo was somewhat languid, and I found my mind wandering. Not poor, simply average. Perhaps more aligned with a different audience's tastes.
Deborah Gomez
Deborah Gomez April 23, 2025
Not entirely to my refined tastes. The tempo was somewhat languid, and I found my mind wandering. Not poor, simply average. Perhaps more aligned with a different audience's tastes.
Laura Lee
Laura Lee October 04, 2025
Exceeded all my expectations. The prose is exquisite. It’s accessible yet undeniably sophisticated. I am now a lifelong fan of this author.
Joseph Taylor
Joseph Taylor August 11, 2024
I thoroughly enjoyed the elegance of it. The protagonist was compelling, though some subplots felt slightly overshadowed. Quite impressive overall.
Jennifer Phillips
Jennifer Phillips February 05, 2025
I thoroughly enjoyed the elegance of it. The protagonist was compelling, though some subplots felt slightly overshadowed. Quite impressive overall.
Cynthia Gonzalez
Cynthia Gonzalez July 14, 2025
Masterpiece from start to finish. The prose is exquisite. It’s accessible yet undeniably sophisticated. A true literary gem.
Linda Young
Linda Young November 21, 2025
I thoroughly enjoyed the elegance of it. Beautiful writing, though I craved slightly more depth in the lore. Still, undeniably engaging. I would highly recommend this to discerning readers.
Brian Martin
Brian Martin September 08, 2024
Absolutely brilliant. I adored how the story unfolded. It kept me captivated without sacrificing elegance. I will undoubtedly revisit this masterpiece.
Brian Ramirez
Brian Ramirez October 16, 2025
A profoundly satisfying read. The author orchestrated a breathtaking finale. Truly a work of art. I will undoubtedly revisit this masterpiece.
Elizabeth Lopez
Elizabeth Lopez July 23, 2025
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I am now a lifelong fan of this author.
George Wright
George Wright August 04, 2024
An acceptable diversion. It possessed moments of brilliance, but the narrative felt slightly disjointed ultimately. Perhaps more aligned with a different audience's tastes.
Anthony Williams
Anthony Williams July 17, 2024
Absolutely brilliant. The prose is exquisite. It’s accessible yet undeniably sophisticated. An absolute must-read for connoisseurs of the genre.
Steven Green
Steven Green August 11, 2025
Excellent, though slightly flawed. A brilliant concept executed with flair. Just a few pacing choices I would change. A wonderful companion for a quiet weekend.
Michael Hernandez
Michael Hernandez December 31, 2024
A very strong entry. The protagonist was compelling, though some subplots felt slightly overshadowed. I would highly recommend this to discerning readers.
Susan Nguyen
Susan Nguyen June 18, 2024
Absolutely brilliant. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An effortless 5 stars.
Jennifer Phillips
Jennifer Phillips February 16, 2025
I was completely blown away. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. Worth every moment spent reading.
Eric Campbell
Eric Campbell July 18, 2025
A decent, if standard, experience. It verged on repetitive in the second act. A more concise edit would have served it well. A fair 3 stars.
Elizabeth Gomez
Elizabeth Gomez March 25, 2025
A profoundly satisfying read. The author orchestrated a breathtaking finale. Truly a work of art. A true literary gem.
Dorothy Brown
Dorothy Brown July 17, 2024
Masterpiece from start to finish. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
Sandra Torres
Sandra Torres August 04, 2024
Exceeded all my expectations. The prose is exquisite. It’s accessible yet undeniably sophisticated. An effortless 5 stars.
Carol Jackson
Carol Jackson April 17, 2024
A highly sophisticated read. A brilliant concept executed with flair. Just a few pacing choices I would change. Quite impressive overall.
Kenneth Jones
Kenneth Jones June 23, 2024
A very strong entry. The protagonist was compelling, though some subplots felt slightly overshadowed. A solid 4 stars from me.
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