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Sjoerdsma, Ann G.'s Starting with Serotonin: How a High-Rolling Father of Drug Discovery Repeatedly Beat the Odds 1st (first) edition by Sjoerdsma, Ann G. published by Improbable Books [Hardcover] (2008)

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Sjoerdsma, Ann G.'s Starting with Serotonin: How a High-Rolling Father of Drug Discovery Repeatedly Beat the Odds 1st (first) edition by Sjoerdsma, Ann G. published by Improbable Books [Hardcover] (2008)

4.85 49,628 ratings · 7,651 reviews
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Overview: When Albert Sjoerdsma, M.D., Ph.D., arrived at the National Institutes of Health in the early 1950s, hypertension still regularly debilitated and killed people. He resolved to change this. Sjoerdsma had read that, when given intravenously, serotonin dramatically elevated a person's blood pressure. Maybe, the young researcher reasoned, he could manipulate serotonin in the body, by blocking a key enzyme in its chemical "pathway," and bring blood pressure down. This was revolutionary thinking. Most drug discovery at the time was a matter of luck, not rational conception. And little was known about serotonin, a "garden-variety" neurotransmitter today, except that it played a role in blood clotting. For twenty years, Sjoerdsma explored wide-ranging, uncharted territory in his Experimental Therapeutics Branch of the National Heart Institute. Launched by his ground-breaking serotonin studies, he diagnosed and defined a cancer known as the carcinoid syndrome; established the mechanism of action of the first antidepressants, which originated in a major drug company's tuberculosis program; measured serotonin, dopamine, and other amines in bananas and other foods, discovered the antihypertensive, Aldomet, a former Top-10 drug; identified treatment for the skin scourge, scleroderma, and the unusual high-blood-pressure disorder, pheochromocytoma; probed the biochemical nature of rapid-eye movement sleep, and much, much more. Because of his inspired work at the NIH and the training he gave his young clinical associates--newly graduated physicians who later spread his research gospel to academia--the tough-talking and straight-shooting Sjoerdsma became known as the Father of Clinical Pharmacology. An advocate of designing drugs that work by inhibiting enzymes, Sjoerdsma went on to enjoy decades-long success as a worldwide leader in the pharmaceutical industry, eventually serving as president of the Merrell Dow Research Institute, headquartered in Cincinnati. With a talented cadre of scientists, the unpredictable innovator developed the first-ever rationally designed antiepileptic (Sabril), also used today to treat a devastating infantile spasm disorder, and the first-ever non-sedating antihistamine, Seldane, replaced in time by its metabolite, Allegra. His crowning glory was the first-ever 100-percent cure for deadly African sleeping sickness--a drug known simply as DFMO. Long before American eyes opened to Third World health tragedies, Sjoerdsma had a lab devoted to research on parasitic diseases, as well as more traditional cancer and heart disease programs. He also contributed to the early treatment of AIDS patients. Gifted at discovery, Al Sjoerdsma always practiced good science, "followed his nose," and optimized the experimental odds in his favor. The research that the Father of Clinical Pharmacology conducted--his brainstorming--still has relevance today in the era of gene-replacement therapy and "Big Pharma." "Starting with Serotonin" shows his prescription for scientific creative freedom and productivity in action--lead by lead by compelling lead.

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Published July 28, 2008
ISBN 132293584
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Ann Sjoerdsma
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Ann Sjoerdsma is a writer and avid reader based in the Pacific Northwest. Before pursuing writing full-time, they spent over a decade working in education. When not working on their next book, Ann Sjoerdsma can usually be found hiking with their dog or trying out new coffee shops in their neighborhood.

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A profoundly satisfying read. The author orchestrated a breathtaking finale. Truly a work of art. An absolute must-read for connoisseurs of the genre.
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I was completely blown away. I adored how the story unfolded. It kept me captivated without sacrificing elegance. Worth every moment spent reading.
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A profoundly satisfying read. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An effortless 5 stars.
Andrew Rivera
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Exceeded all my expectations. The author orchestrated a breathtaking finale. Truly a work of art. I will undoubtedly revisit this masterpiece.
Gary Lopez
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Absolutely brilliant. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. Worth every moment spent reading.
Mary Flores
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I thoroughly enjoyed the elegance of it. The middle had a deliberate pace, but the climax was phenomenal. I would highly recommend this to discerning readers.
Cynthia Jones
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I was completely blown away. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. A true literary gem.
Barbara Gomez
Barbara Gomez March 27, 2024
A very strong entry. The protagonist was compelling, though some subplots felt slightly overshadowed. Quite impressive overall.
Gary Robinson
Gary Robinson November 17, 2024
Masterpiece from start to finish. The author orchestrated a breathtaking finale. Truly a work of art. I will undoubtedly revisit this masterpiece.
Charles Reyes
Charles Reyes May 20, 2024
Masterpiece from start to finish. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An absolute must-read for connoisseurs of the genre.
Richard Taylor
Richard Taylor April 17, 2025
I thoroughly enjoyed the elegance of it. The middle had a deliberate pace, but the climax was phenomenal. A solid 4 stars from me.
Robert  Davis
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I find myself somewhat conflicted. The prose was competent, yet the characters lacked the depth I usually seek. Unlikely to reread, but a reasonable expenditure of time.
Robert Scott
Robert Scott March 25, 2024
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An effortless 5 stars.
Donald Perez
Donald Perez June 30, 2025
Excellent, though slightly flawed. Beautiful writing, though I craved slightly more depth in the lore. Still, undeniably engaging. A wonderful companion for a quiet weekend.
Michael Jones
Michael Jones March 28, 2025
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Elizabeth Evans
Elizabeth Evans February 21, 2025
Masterpiece from start to finish. The prose is exquisite. It’s accessible yet undeniably sophisticated. Worth every moment spent reading.
Ashley Clark
Ashley Clark September 12, 2025
Absolutely brilliant. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An absolute must-read for connoisseurs of the genre.
Nicholas Nguyen
Nicholas Nguyen August 17, 2025
Not entirely to my refined tastes. It verged on repetitive in the second act. A more concise edit would have served it well. A fair 3 stars.
Paul Hill
Paul Hill August 12, 2024
A profoundly satisfying read. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
Barbara Gonzalez
Barbara Gonzalez April 07, 2024
Masterpiece from start to finish. I adored how the story unfolded. It kept me captivated without sacrificing elegance. Worth every moment spent reading.
Charles White
Charles White November 05, 2025
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Stephanie Green
Stephanie Green April 07, 2024
I was completely blown away. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
Emily Lopez
Emily Lopez July 18, 2024
I was completely blown away. The author orchestrated a breathtaking finale. Truly a work of art. I will undoubtedly revisit this masterpiece.
Joshua Collins
Joshua Collins May 01, 2025
Such a rich narrative. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. An effortless 5 stars.
Edward Brown
Edward Brown January 12, 2024
Masterpiece from start to finish. The prose is exquisite. It’s accessible yet undeniably sophisticated. An absolute must-read for connoisseurs of the genre.
Kenneth Young
Kenneth Young June 29, 2025
A very strong entry. The middle had a deliberate pace, but the climax was phenomenal. I would highly recommend this to discerning readers.
Karen Edwards
Karen Edwards May 24, 2024
Honestly one of the most premium reading experiences lately. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. Worth every moment spent reading.
Nicholas Gonzalez
Nicholas Gonzalez February 16, 2024
A very strong entry. It held my rapt attention, even when certain twists were telegraphed. A very distinguished novel.
Dorothy Young
Dorothy Young October 27, 2024
I thoroughly enjoyed the elegance of it. A brilliant concept executed with flair. Just a few pacing choices I would change. A solid 4 stars from me.
Sharon Taylor
Sharon Taylor March 15, 2024
It was adequate. Certain acts were fascinating, while others felt like a slight endeavor to complete. Unlikely to reread, but a reasonable expenditure of time.
Michael Roberts
Michael Roberts April 13, 2024
Exceeded all my expectations. The author orchestrated a breathtaking finale. Truly a work of art. An effortless 5 stars.
Mary Flores
Mary Flores October 11, 2025
Took a moment to build, but the payoff was spectacular. Beautiful writing, though I craved slightly more depth in the lore. Still, undeniably engaging. A solid 4 stars from me.
Mary Flores
Mary Flores May 17, 2024
I was completely blown away. I adored how the story unfolded. It kept me captivated without sacrificing elegance. Worth every moment spent reading.
Linda Lopez
Linda Lopez December 20, 2024
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I am now a lifelong fan of this author.
Nancy Carter
Nancy Carter September 11, 2024
I was completely blown away. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. An absolute must-read for connoisseurs of the genre.
Kimberly Johnson
Kimberly Johnson October 20, 2025
Such a rich narrative. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. I am now a lifelong fan of this author.
Melissa Thompson
Melissa Thompson November 18, 2024
A profoundly satisfying read. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. An effortless 5 stars.
Laura Mitchell
Laura Mitchell March 22, 2025
Exceeded all my expectations. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. Worth every moment spent reading.
Gary Jones
Gary Jones August 25, 2025
Exceeded all my expectations. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. Worth every moment spent reading.
Betty Robinson
Betty Robinson September 27, 2025
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An absolute must-read for connoisseurs of the genre.
Laura Brown
Laura Brown January 29, 2025
Absolutely brilliant. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. An effortless 5 stars.
Mark Anderson
Mark Anderson December 13, 2024
I was completely blown away. I adored how the story unfolded. It kept me captivated without sacrificing elegance. An absolute must-read for connoisseurs of the genre.
Daniel Cruz
Daniel Cruz April 23, 2025
Masterpiece from start to finish. I adored how the story unfolded. It kept me captivated without sacrificing elegance. A true literary gem.
Michael Roberts
Michael Roberts November 01, 2025
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. Worth every moment spent reading.
Joseph Hernandez
Joseph Hernandez October 25, 2024
An acceptable diversion. Certain acts were fascinating, while others felt like a slight endeavor to complete. Suitable if your reading queue is empty.
Dorothy Young
Dorothy Young July 16, 2024
Honestly one of the most premium reading experiences lately. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An absolute must-read for connoisseurs of the genre.
Christopher Smith
Christopher Smith December 18, 2024
Such a rich narrative. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. A true literary gem.
Anthony Cruz
Anthony Cruz August 21, 2024
Excellent, though slightly flawed. It held my rapt attention, even when certain twists were telegraphed. I would highly recommend this to discerning readers.
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